Capturing cell heterogeneity in representations of cell populations for image-based profiling using contrastive learning.
Image-based cell profiling is a powerful tool that compares perturbed cell populations by measuring thousands of single-cell features and summarizing them into profiles.Typically a sample is represented by averaging across cells, but this fails to capture the heterogeneity within cell populations.We introduce CytoSummaryNet: a Deep Sets-based appro